{"product_id":"cjc-1295","title":"CJC-1295 NO DAC (Mod GRF 1-29)","description":"\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp dir=\"auto\" style=\"white-space: pre-wrap;\"\u003e\u003cstrong\u003eCJC-1295 No DAC\u003c\/strong\u003e (also known as \u003cstrong\u003eMod GRF (1-29)\u003c\/strong\u003e or \u003cstrong\u003etetrasubstituted GRF (1-29)\u003c\/strong\u003e) is a \u003cstrong\u003esynthetic 29-amino-acid polypeptide\u003c\/strong\u003e analog of \u003cstrong\u003egrowth hormone-releasing hormone\u003c\/strong\u003e (\u003cstrong\u003eGHRH\u003c\/strong\u003e), featuring four strategic amino acid substitutions (at positions 2, 8, 15, and 27) designed to dramatically enhance stability and resistance to enzymatic degradation compared to native GHRH. Unlike the DAC-containing version, CJC-1295 No DAC has a short half-life (approximately 6–8 minutes), resulting in more physiological, pulsatile stimulation of endogenous \u003cstrong\u003egrowth hormone\u003c\/strong\u003e (\u003cstrong\u003eGH\u003c\/strong\u003e) secretion. This research compound has attracted significant scientific interest for its potent and selective activation of pituitary somatotropes. Preliminary and advanced preclinical studies indicate that CJC-1295 No DAC may robustly increase GH and \u003cstrong\u003eIGF-1\u003c\/strong\u003e levels in a natural pulsatile pattern, support anabolic processes, enhance recovery, and promote favorable changes in body composition. Researchers utilize this peptide in laboratory and animal models to investigate mechanisms of GH axis physiology, pulsatile hormone release, tissue repair, and age-related endocrine modulation. As a research-grade compound, CJC-1295 No DAC is intended exclusively for in vitro and animal studies. Scientists value its clean pharmacokinetic profile, minimal off-target hormonal effects, and utility in studying natural GH pulsatility versus sustained release patterns.\u003c\/p\u003e\n\u003ch3 dir=\"auto\"\u003eKey Research Applications\u003c\/h3\u003e\n\u003cul dir=\"auto\"\u003e\n\u003cli\u003e\n\u003cstrong\u003ePulsatile Growth Hormone Secretion\u003c\/strong\u003e — Preclinical investigations demonstrate that CJC-1295 No DAC elicits strong, dose-dependent, and naturally pulsatile GH release by activating GHRH receptors on pituitary somatotrophs. Studies emphasize its ability to mimic physiological GH secretion patterns more closely than long-acting analogs, preserving feedback regulation.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBody Composition and Anabolic Research\u003c\/strong\u003e — Research shows increases in lean body mass, improvements in nitrogen retention, and enhanced protein synthesis in various animal models. It has been explored for potential applications in sarcopenia, cachexia, muscle wasting, and post-injury recovery.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSynergistic Secretagogue Combinations\u003c\/strong\u003e — CJC-1295 No DAC is frequently studied in combination with GHS compounds (e.g., Ipamorelin, GHRP-6) to achieve synergistic amplification of GH pulses, resulting in greater overall GH\/IGF-1 output while maintaining selectivity and minimizing side effects.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFat Metabolism and Lipolysis\u003c\/strong\u003e — Investigations indicate enhanced lipolytic activity and reductions in fat mass in preclinical obesity and metabolic models, often attributed to elevated GH levels and improved insulin sensitivity in certain contexts.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTissue Repair and Recovery\u003c\/strong\u003e — Studies suggest benefits in accelerating wound healing, tendon\/ligament repair, cartilage regeneration, and bone metabolism through GH\/IGF-1-mediated pathways. Research explores its role in models of aging, traumatic injury, and surgical recovery.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3 dir=\"auto\"\u003eTechnical Specifications\u003c\/h3\u003e\n\u003cul dir=\"auto\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Formula\u003c\/strong\u003e: C₁₅₂H₂₅₂N₄₄O₄₂\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Weight\u003c\/strong\u003e: 3367.9 g\/mol\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSequence\u003c\/strong\u003e: Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH₂ (C-terminal amidation; key substitutions: D-Ala², Gln⁸, Ala¹⁵, Leu²⁷)\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e","brand":"Omni Peptides","offers":[{"title":"5mg","offer_id":50722256650487,"sku":null,"price":250.0,"currency_code":"AED","in_stock":false},{"title":"10mg","offer_id":50722256683255,"sku":"CND10","price":400.0,"currency_code":"AED","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0918\/6777\/5223\/files\/modgrf129_5mg.png?v=1777536871","url":"https:\/\/dubaipeptides.ae\/products\/cjc-1295","provider":"Dubai Peptides","version":"1.0","type":"link"}