{"product_id":"foxo4-dri","title":"FOXO4-DRI","description":"\u003cp dir=\"auto\"\u003e\u003cstrong\u003eFOXO4-DRI\u003c\/strong\u003e (also known as \u003cstrong\u003eFOXO4-D-Retro-Inverso\u003c\/strong\u003e, \u003cstrong\u003eProxofim\u003c\/strong\u003e, or \u003cstrong\u003eFOXO4-DRI peptide\u003c\/strong\u003e) is a \u003cstrong\u003esynthetic cell-permeable retro-inverso peptide\u003c\/strong\u003e composed entirely of D-amino acids. It is designed as a competitive antagonist that mimics the p53-binding domain of the \u003cstrong\u003eFOXO4\u003c\/strong\u003e (Forkhead box O4) transcription factor, thereby selectively disrupting the FOXO4-p53 interaction. This research compound has attracted substantial scientific interest as a prototype \u003cstrong\u003esenolytic\u003c\/strong\u003e agent that preferentially induces apoptosis in \u003cstrong\u003esenescent cells\u003c\/strong\u003e while largely sparing healthy proliferating cells. Preliminary and advanced preclinical studies demonstrate that FOXO4-DRI promotes nuclear exclusion of p53 in senescent cells, redirects it toward mitochondrial pathways, triggers cytochrome c release and caspase activation, and ultimately clears senescent populations. Researchers utilize FOXO4-DRI in laboratory and animal models to investigate mechanisms of cellular senescence, tissue homeostasis restoration, age-related pathologies, chemotherapy-induced toxicity, and regenerative interventions. As a research-grade compound, FOXO4-DRI is intended exclusively for in vitro and animal studies. Scientists value its high selectivity, enhanced proteolytic stability due to the D-amino acid and retro-inverso design, and its role in advancing understanding of FOXO4-p53 axis-mediated senescence survival.\u003c\/p\u003e\n\u003ch3 dir=\"auto\"\u003eKey Research Applications\u003c\/h3\u003e\n\u003cul dir=\"auto\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eSelective Clearance of Senescent Cells\u003c\/strong\u003e — Preclinical studies show FOXO4-DRI potently and selectively induces apoptosis in senescent fibroblasts, chondrocytes, endothelial cells, Leydig cells, and other cell types by disrupting FOXO4-p53 complexes in PML bodies\/DNA-SCARS, leading to p53 mitochondrial translocation and execution of the apoptotic program.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReversal of Age-Related Tissue Dysfunction\u003c\/strong\u003e — In naturally aged and accelerated-aging mouse models, FOXO4-DRI restores multiple fitness markers (including renal function, fur density, physical performance, and overall tissue homeostasis) by eliminating accumulated senescent cells and reducing the senescence-associated secretory phenotype (SASP).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eChemotherapy-Induced Toxicity Mitigation\u003c\/strong\u003e — Investigations reveal that FOXO4-DRI alleviates doxorubicin-induced chemotoxicity by targeting senescent cells in affected tissues (e.g., kidney, liver), reducing inflammation and helping restore organ function after chemotherapeutic stress.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReproductive and Endocrine Health\u003c\/strong\u003e — Research demonstrates benefits in age-related testosterone insufficiency models by selectively removing senescent Leydig cells in the testes, improving the testicular microenvironment, spermatogenesis, and hormone secretion in aged mice.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBroader Regenerative and Disease Models\u003c\/strong\u003e — Emerging studies explore applications in models of vascular aging (endothelial senescence), keloid formation, osteoarthritis (chondrocyte senescence), and other senescence-driven pathologies, highlighting its potential to enhance tissue regeneration and counteract chronic inflammation.\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Omni Peptides","offers":[{"title":"10 MG","offer_id":51004262809847,"sku":null,"price":1350.0,"currency_code":"AED","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0918\/6777\/5223\/files\/foxo4_10mg.png?v=1786108865","url":"https:\/\/dubaipeptides.ae\/products\/foxo4-dri","provider":"Dubai Peptides","version":"1.0","type":"link"}