Omni Peptides
Glutathione
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Reduces oxidative stress, liver support, skin brightening
Glutathione (GSH) is a synthetic or recombinantly produced form of the naturally occurring tripeptide thiol composed of glutamate, cysteine, and glycine. This ubiquitous intracellular antioxidant has attracted extensive scientific interest as the body’s principal low-molecular-weight thiol and master regulator of cellular redox homeostasis. Preliminary and advanced preclinical studies indicate that glutathione supplementation or restoration may directly neutralize reactive oxygen species (ROS), serve as a cofactor for glutathione peroxidase and other detoxifying enzymes, regenerate other antioxidants (e.g., vitamins C and E), support phase II detoxification, modulate inflammatory signaling, and protect mitochondrial function. Researchers utilize glutathione in laboratory and animal models to investigate mechanisms of oxidative stress, detoxification pathways, mitochondrial health, neurodegeneration, liver injury, immune regulation, and aging-related redox imbalance. As a research-grade compound, glutathione is intended exclusively for in vitro and animal studies. Scientists value its central role in the cellular antioxidant network, its sensitivity to synthesis and recycling pathways, and its utility in elucidating redox-dependent cellular processes across multiple organ systems.
Research Applications
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Antioxidant Defense and ROS ScavengingPreclinical investigations demonstrate that glutathione directly quenches free radicals, peroxides, and electrophiles, while maintaining redox-sensitive proteins in their reduced state. Studies frequently explore its protective effects against oxidative insults in models of ischemia-reperfusion, radiation, and chemical toxicity.
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Liver Health and DetoxificationGlutathione is heavily studied for its critical role in hepatic phase II conjugation (via glutathione S-transferases) and protection against hepatotoxins (e.g., acetaminophen, ethanol, heavy metals). Research highlights its depletion in models of acute liver injury, non-alcoholic fatty liver disease (NAFLD/MASLD), and fibrosis, with restoration linked to improved outcomes.
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Neuroprotection and CNS DisordersExtensive studies show glutathione depletion in models of Parkinson’s disease, Alzheimer’s disease, stroke, and traumatic brain injury. Supplementation or precursor strategies are investigated for preserving neuronal mitochondrial function, reducing protein aggregation, mitigating neuroinflammation, and protecting dopaminergic and other neuronal populations.
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Mitochondrial Function and Energy MetabolismGlutathione maintains mitochondrial redox balance, prevents cardiolipin peroxidation, supports electron transport chain efficiency, and protects against mitochondrial permeability transition. Research explores its role in age-related mitochondrial decline, metabolic disorders, and conditions involving bioenergetic failure.
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Immune Modulation and Inflammation ControlGlutathione regulates NF-κB activity, T-cell proliferation, cytokine production, and macrophage polarization. Investigations examine its influence on chronic inflammatory states, autoimmune models, sepsis, and viral infections, where redox status profoundly impacts immune cell function and resolution of inflammation.
Storage & Handling
Storage & Handling
Lyophilised vials are stable at −20°C for up to 2 years unopened. Once reconstituted, refrigerate at 2–8°C and use within 28 days. Avoid repeated freeze-thaw cycles.
Beyond Use Date
Pre-filled formats (cartridge, pen, nasal) carry a beyond-use date of typically 4–8 weeks from receipt. ≥98% purity by HPLC. For in vitro and preclinical research use only — not for human or veterinary use.