{"product_id":"humanin","title":"Humanin","description":"\u003cp dir=\"auto\"\u003e\u003cstrong\u003eHumanin\u003c\/strong\u003e is a \u003cstrong\u003esynthetic mitochondrial-derived peptide\u003c\/strong\u003e (MDP) consisting of 24 amino acids, encoded by a short open reading frame within the 16S ribosomal RNA gene (MT-RNR2) of the mitochondrial genome. This research compound has attracted substantial scientific interest as one of the most potent and well-characterized cytoprotective and neuroprotective peptides identified to date. Preliminary and advanced preclinical studies demonstrate that humanin exerts broad protective effects against cellular stress, apoptosis, oxidative damage, and inflammation through multiple mechanisms, including interaction with extracellular receptors (e.g., FPRL1\/formyl peptide receptor-like 1), intracellular binding partners (e.g., Bax, Bid, IGFBP-3), and modulation of STAT3, ERK, and AKT signaling pathways. Researchers utilize humanin (and its more potent analogs such as HNG or HN-F6A) in laboratory and animal models to investigate mechanisms of mitochondrial-mediated cytoprotection, neurodegeneration, metabolic disorders, cardiovascular disease, and aging-related pathologies. As a research-grade compound, humanin is intended exclusively for in vitro and animal studies. Scientists value its remarkable potency at nanomolar to picomolar concentrations, its ability to cross the blood-brain barrier, and its potential as a prototype for developing mitochondrially-targeted therapeutics.\u003c\/p\u003e\n\u003ch3 dir=\"auto\"\u003eKey Research Applications\u003c\/h3\u003e\n\u003cul dir=\"auto\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eNeuroprotection and Neurodegenerative Disease Models\u003c\/strong\u003e — Humanin potently protects neurons from amyloid-β toxicity, oxidative stress, and serum deprivation in Alzheimer’s disease models. It reduces tau hyperphosphorylation, inhibits Aβ-induced apoptosis, and improves cognitive function in transgenic AD mouse models. Studies also show benefits in Parkinson’s, ALS, and stroke models by preserving mitochondrial integrity and reducing neuronal loss.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMitochondrial Function and Cytoprotection\u003c\/strong\u003e — Humanin stabilizes mitochondrial membrane potential, prevents Bax\/Bak oligomerization, blocks cytochrome c release, and inhibits the mitochondrial permeability transition pore. It protects against ischemia-reperfusion injury in heart, brain, and retina, and ameliorates mitochondrial dysfunction in various stress paradigms.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMetabolic Health and Diabetes\u003c\/strong\u003e — Investigations reveal that humanin improves insulin sensitivity, enhances glucose uptake, reduces hepatic glucose production, and protects pancreatic β-cells from cytokine-induced apoptosis in models of type 1 and type 2 diabetes. It also mitigates diabetic retinopathy and nephropathy in preclinical models.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCardiovascular Protection\u003c\/strong\u003e — Humanin reduces myocardial infarct size, improves post-ischemic cardiac function, and protects endothelial cells from oxidative damage and atherosclerosis progression. Research highlights its anti-apoptotic and anti-inflammatory effects in cardiomyocytes and vascular tissues.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAging, Longevity, and Systemic Protection\u003c\/strong\u003e — Circulating humanin levels decline with age in humans and rodents. Supplementation in aged animals extends healthspan markers, reduces inflammation, improves metabolic parameters, and protects against age-related pathologies including sarcopenia, macular degeneration, and hearing loss.\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Omni Peptides","offers":[{"title":"10 MG","offer_id":51018139009271,"sku":"HUM10","price":850.0,"currency_code":"AED","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0918\/6777\/5223\/files\/humanin_10mg.png?v=1788037231","url":"https:\/\/dubaipeptides.ae\/products\/humanin","provider":"Dubai Peptides","version":"1.0","type":"link"}