{"product_id":"melanotan-i","title":"Melanotan I","description":"\u003cp dir=\"auto\"\u003e\u003cstrong\u003eMelanotan I\u003c\/strong\u003e (also known as \u003cstrong\u003eMelanotan-1\u003c\/strong\u003e, \u003cstrong\u003eAfamelanotide\u003c\/strong\u003e, or \u003cstrong\u003e[Nle⁴, D-Phe⁷]-α-MSH\u003c\/strong\u003e) is a \u003cstrong\u003esynthetic linear tridecapeptide\u003c\/strong\u003e analog of \u003cstrong\u003ealpha-melanocyte-stimulating hormone\u003c\/strong\u003e (α-MSH). This research compound was designed for selective agonism at the \u003cstrong\u003emelanocortin-1 receptor\u003c\/strong\u003e (\u003cstrong\u003eMC1R\u003c\/strong\u003e) with improved potency and enzymatic stability compared to native α-MSH. It has attracted significant scientific interest for its potent stimulation of \u003cstrong\u003eeumelanin synthesis\u003c\/strong\u003e, photoprotection, and potential tissue-protective effects without the strong central melanocortin activity (MC3R\/MC4R) that characterizes Melanotan II.\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003ePreliminary and advanced preclinical studies indicate that Melanotan I robustly activates melanocytes to increase melanin production, enhances UV resistance, and may exert anti-inflammatory and cytoprotective actions. Researchers utilize this peptide in laboratory and animal models to investigate mechanisms of melanogenesis, photobiology, skin pigmentation disorders, and melanocortin receptor signaling. As a research-grade compound, Melanotan I is intended exclusively for in vitro and animal studies (note: afamelanotide has received regulatory approval in certain jurisdictions for erythropoietic protoporphyria under the brand Scenesse, but research formulations remain designated for laboratory use). Scientists value its higher MC1R selectivity relative to Melanotan II, linear structure, and utility in studying targeted pigmentation pathways with reduced off-target central effects.\u003c\/p\u003e\n\u003ch3 dir=\"auto\"\u003eKey Research Applications\u003c\/h3\u003e\n\u003cul dir=\"auto\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eMelanogenesis and Photoprotection\u003c\/strong\u003e — Preclinical investigations demonstrate potent MC1R-mediated stimulation of eumelanin production in melanocytes, leading to increased skin pigmentation and enhanced resistance to UV-induced damage. Studies explore its potential in models of photoprotection, sunburn prevention, and pigmentary disorders.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSkin and Dermatological Research\u003c\/strong\u003e — Melanotan I is studied for its ability to modulate melanocyte activity, improve barrier function, and reduce oxidative stress in UV-exposed or injured skin models. Research examines applications in vitiligo-like conditions and photodermatoses.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAnti-Inflammatory and Cytoprotective Effects\u003c\/strong\u003e — Investigations highlight reductions in pro-inflammatory signaling and cellular damage in models of skin injury, inflammation, and oxidative stress, with mechanisms linked to MC1R activation beyond pure pigmentation.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eComparison to Melanotan II\u003c\/strong\u003e — Unlike the cyclic Melanotan II (which strongly activates MC3R\/MC4R and produces erectogenic and appetite-suppressant effects), Melanotan I shows preferential MC1R activity with minimal central nervous system or sexual side-effect profiles in research models.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBroader Melanocortin Biology\u003c\/strong\u003e — Emerging studies probe its influence on immune modulation, wound healing, and potential systemic effects mediated by peripheral melanocortin receptors.\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Omni Peptides","offers":[{"title":"10 MG","offer_id":51002087178487,"sku":null,"price":200.0,"currency_code":"AED","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0918\/6777\/5223\/files\/mt1_10mg.png?v=1786034827","url":"https:\/\/dubaipeptides.ae\/products\/melanotan-i","provider":"Dubai Peptides","version":"1.0","type":"link"}