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Omni Peptides

Melanotan II

Regular price Dhs. 200.00 AED
Regular price Sale price Dhs. 200.00 AED
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MT-2 (Melanotan II, also known as MTII or Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂) is a synthetic cyclic heptapeptide analog of alpha-melanocyte-stimulating hormone (α-MSH). This research compound has garnered extensive scientific interest for its potent, non-selective agonism at multiple melanocortin receptors (MC1R, MC3R, MC4R, MC5R), with particularly strong activity at MC1R and MC4R. Preliminary and advanced preclinical studies indicate that MT-2 may robustly stimulate melanogenesis (skin and hair pigmentation), induce erections via central melanocortin pathways, modulate sexual behavior, suppress appetite, and influence energy homeostasis. Researchers utilize MT-2 in laboratory and animal models to investigate mechanisms of melanocortin receptor signaling, pigmentation biology, sexual function, obesity, and neuroendocrine regulation. As a research-grade compound, MT-2 is intended exclusively for in vitro and animal studies. Scientists value its enhanced potency, prolonged duration of action compared to native α-MSH, and its utility in dissecting the pleiotropic effects of melanocortin receptor activation across dermatological, reproductive, and metabolic research domains.

Molecular Formula
C₅₀H₆₉N₁₅O₉
Molecular Weight
1024.2 g/mol
Sequence
Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂ (cyclic heptapeptide lactam; Nle = norleucine; D-Phe = D-phenylalanine; N-terminal acetylation, C-terminal amidation)
  • Melanogenesis and Photoprotection
    Preclinical investigations demonstrate that MT-2 potently activates MC1R on melanocytes, leading to dose-dependent increases in eumelanin synthesis, skin darkening, and enhanced UV photoprotection. Studies explore its potential in models of UV-induced damage, sunburn prevention, and pigmentary disorders.
  • Sexual Function and Erectile Response
    MT-2 induces penile erections and increases sexual desire through central activation of melanocortin pathways (primarily MC4R) in the hypothalamus and other brain regions. Research frequently examines its rapid-onset erectogenic effects in various animal models, including those with vascular or neurogenic erectile dysfunction.
  • Appetite Suppression and Metabolic Regulation
    Investigations show MT-2 reduces food intake, decreases body weight, and improves metabolic parameters in obesity models via MC4R-mediated effects in the central nervous system. Studies compare its anorexigenic potency to other melanocortin agonists and explore interactions with leptin and other feeding circuits.
  • Neuroendocrine and Behavioral Effects
    MT-2 modulates sexual motivation, partner preference, grooming behavior, and stress-related responses in preclinical models. Research probes its influence on hypothalamic-pituitary-adrenal axis activity, reward pathways, and potential applications in models of hypoactive sexual desire or compulsive behaviors.
  • Broader Physiological and Dermatological Implications
    Emerging studies investigate MT-2’s roles in inflammation modulation, cardiovascular effects, neuroprotection, and tissue remodeling, with particular interest in its MC1R-independent actions and potential in models of skin cancer prevention, alopecia, and metabolic syndrome.
Storage & Handling

Lyophilised vials are stable at −20°C for up to 2 years unopened. Once reconstituted, refrigerate at 2–8°C and use within 28 days. Avoid repeated freeze-thaw cycles.

Beyond Use Date

Pre-filled formats (cartridge, pen, nasal) carry a beyond-use date of typically 4–8 weeks from receipt. ≥98% purity by HPLC. For in vitro and preclinical research use only — not for human or veterinary use.