{"product_id":"pt-141","title":"PT-141","description":"\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp dir=\"auto\" style=\"white-space: pre-wrap;\"\u003e\u003cstrong\u003ePT-141\u003c\/strong\u003e (also known as \u003cstrong\u003eBremelanotide\u003c\/strong\u003e or \u003cstrong\u003ePT141\u003c\/strong\u003e) is a \u003cstrong\u003esynthetic cyclic heptapeptide\u003c\/strong\u003e analog of \u003cstrong\u003ealpha-melanocyte-stimulating hormone\u003c\/strong\u003e (α-MSH). This research compound has attracted substantial scientific interest for its selective agonism at \u003cstrong\u003emelanocortin receptors\u003c\/strong\u003e (primarily MC3R and MC4R), predominantly expressed in the central nervous system. Preliminary and advanced preclinical studies indicate that PT-141 may activate hypothalamic pathways to enhance sexual arousal and desire, induce penile erections in animal models, and modulate sexual behavior without direct reliance on vascular mechanisms. Researchers utilize this peptide in laboratory and animal models to investigate mechanisms of central sexual response, libido regulation, hypoactive sexual desire disorder (HSDD), and erectile dysfunction. As a research-grade compound, PT-141 is intended exclusively for in vitro and animal studies (note: bremelanotide has received regulatory approval for specific clinical indications such as HSDD in premenopausal women under the brand Vyleesi, but research formulations remain designated for laboratory use). Scientists value its unique CNS-targeted action, distinguishing it from PDE5 inhibitors, and its utility in elucidating melanocortin-mediated pathways in reproductive neuroendocrinology.\u003c\/p\u003e\n\u003ch3 dir=\"auto\"\u003eKey Research Applications\u003c\/h3\u003e\n\u003cul dir=\"auto\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eSexual Arousal and Desire Enhancement\u003c\/strong\u003e — Preclinical investigations demonstrate that PT-141 potently activates melanocortin receptors in the hypothalamus, increasing sexual motivation, arousal, and desire in various animal models. It elicits dose-dependent penile erections in rats and nonhuman primates via central neural pathways, with activation confirmed by c-Fos expression in relevant brain regions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eErectile Function Studies\u003c\/strong\u003e — Research shows PT-141 induces erectile responses in normal and erectile dysfunction models, often with synergistic effects when combined with PDE5 inhibitors like sildenafil. Studies explore its rapid onset and CNS-mediated mechanism as a potential alternative or adjunct for vascular-independent erectile support.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHypoactive Sexual Desire Disorder (HSDD) Models\u003c\/strong\u003e — PT-141 is extensively studied for restoring sexual desire in models of low libido, including female HSDD. It modulates brain pathways involved in sexual response, offering insights into non-hormonal approaches to female sexual dysfunction.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNeuroendocrine and Behavioral Effects\u003c\/strong\u003e — Investigations highlight PT-141's influence on sexual behaviors, partner preference, and arousal networks in the brain. Research examines its specificity for melanocortin receptors without significant tanning effects (unlike related melanotan analogs) and its potential in broader reproductive behavior models.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBroader CNS and Physiological Implications\u003c\/strong\u003e — Emerging studies probe its roles in modulating other melanocortin-mediated functions, including potential interactions with appetite, stress, and reward pathways, with implications for understanding central regulation of sexual and motivational states.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3 dir=\"auto\"\u003eTechnical Specifications\u003c\/h3\u003e\n\u003cul dir=\"auto\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Formula\u003c\/strong\u003e: C₅₀H₆₈N₁₄O₁₀\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Weight\u003c\/strong\u003e: 1025.2 g\/mol\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSequence\u003c\/strong\u003e: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH (cyclic heptapeptide lactam; Nle = norleucine; D-Phe = D-phenylalanine; C-terminal carboxylic acid)\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e","brand":"Omni Peptides","offers":[{"title":"10mg","offer_id":50722294595831,"sku":null,"price":250.0,"currency_code":"AED","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0918\/6777\/5223\/files\/pt141_10mg.png?v=1777537085","url":"https:\/\/dubaipeptides.ae\/products\/pt-141","provider":"Dubai Peptides","version":"1.0","type":"link"}