Omni Peptides
Tesamorelin
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GHRH analog; strongest visceral/abdominal fat burner, clean GH/IGF-1 boost
Tesamorelin (also known as TH9507) is a synthetic 44-amino-acid polypeptide analog of human growth hormone-releasing hormone (GHRH), featuring an N-terminal modification with a trans-3-hexenoyl group for enhanced stability and resistance to enzymatic degradation. This research compound has garnered significant scientific interest for its ability to stimulate pulsatile endogenous growth hormone (GH) secretion from the anterior pituitary, thereby elevating insulin-like growth factor-1 (IGF-1) levels and influencing metabolic pathways. Preliminary and advanced preclinical studies indicate that tesamorelin may promote lipolysis, reduce visceral adipose tissue, support muscle preservation, and modulate body composition. Researchers employ this peptide in laboratory and animal models to investigate mechanisms of GH axis regulation, fat metabolism, and endocrine responses, particularly in models of metabolic dysregulation and age-related decline. As a research-grade compound, tesamorelin is intended exclusively for in vitro and animal studies. Scientists value its improved pharmacokinetic profile over native GHRH and its utility in elucidating targeted GH stimulation without direct exogenous hormone administration.
Research Applications
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Visceral Adipose Tissue ReductionPreclinical and clinical-model studies demonstrate that tesamorelin significantly decreases visceral fat accumulation through enhanced lipolysis and triglyceride reduction. It has been extensively investigated in models of HIV-associated lipodystrophy and central obesity, showing preferential effects on abdominal fat while preserving subcutaneous adipose tissue.
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Growth Hormone Axis StimulationTesamorelin potently activates GHRH receptors to induce pulsatile GH release and elevate IGF-1 levels. Research explores its role in restoring GH secretion in states of relative deficiency, including aging, metabolic syndrome, and antiretroviral therapy-related endocrine disruption.
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Body Composition and Muscle HealthInvestigations reveal tesamorelin's potential to increase lean muscle area and density in truncal muscle groups, while improving muscle quality metrics (e.g., Hounsfield units) in models of sarcopenia and fat infiltration. Studies assess its anabolic effects alongside fat loss for better overall body composition.
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Metabolic and Lipid Profile ModulationTesamorelin favorably influences lipid metabolism, insulin sensitivity, and energy balance in preclinical models. Research examines its impact on triglycerides, liver fat, and metabolic parameters in obesity and diabetes-related contexts.
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Broader Endocrine and Protective EffectsEmerging studies probe its applications in neuroprotection, cardiovascular health, and age-related metabolic decline, with implications for investigating GH-mediated anabolic and lipolytic pathways across multiple organ systems.
Storage & Handling
Storage & Handling
Lyophilised vials are stable at −20°C for up to 2 years unopened. Once reconstituted, refrigerate at 2–8°C and use within 28 days. Avoid repeated freeze-thaw cycles.
Beyond Use Date
Pre-filled formats (cartridge, pen, nasal) carry a beyond-use date of typically 4–8 weeks from receipt. ≥98% purity by HPLC. For in vitro and preclinical research use only — not for human or veterinary use.