Omni Peptides
CJC-1295 NO DAC (Mod GRF 1-29)
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CJC-1295 No DAC (also known as Mod GRF (1-29) or tetrasubstituted GRF (1-29)) is a synthetic 29-amino-acid polypeptide analog of growth hormone-releasing hormone (GHRH), featuring four strategic amino acid substitutions (at positions 2, 8, 15, and 27) designed to dramatically enhance stability and resistance to enzymatic degradation compared to native GHRH. Unlike the DAC-containing version, CJC-1295 No DAC has a short half-life (approximately 6–8 minutes), resulting in more physiological, pulsatile stimulation of endogenous growth hormone (GH) secretion. This research compound has attracted significant scientific interest for its potent and selective activation of pituitary somatotropes. Preliminary and advanced preclinical studies indicate that CJC-1295 No DAC may robustly increase GH and IGF-1 levels in a natural pulsatile pattern, support anabolic processes, enhance recovery, and promote favorable changes in body composition. Researchers utilize this peptide in laboratory and animal models to investigate mechanisms of GH axis physiology, pulsatile hormone release, tissue repair, and age-related endocrine modulation. As a research-grade compound, CJC-1295 No DAC is intended exclusively for in vitro and animal studies. Scientists value its clean pharmacokinetic profile, minimal off-target hormonal effects, and utility in studying natural GH pulsatility versus sustained release patterns.
Research Applications
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Pulsatile Growth Hormone SecretionPreclinical investigations demonstrate that CJC-1295 No DAC elicits strong, dose-dependent, and naturally pulsatile GH release by activating GHRH receptors on pituitary somatotrophs. Studies emphasize its ability to mimic physiological GH secretion patterns more closely than long-acting analogs, preserving feedback regulation.
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Body Composition and Anabolic ResearchResearch shows increases in lean body mass, improvements in nitrogen retention, and enhanced protein synthesis in various animal models. It has been explored for potential applications in sarcopenia, cachexia, muscle wasting, and post-injury recovery.
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Synergistic Secretagogue CombinationsCJC-1295 No DAC is frequently studied in combination with GHS compounds (e.g., Ipamorelin, GHRP-6) to achieve synergistic amplification of GH pulses, resulting in greater overall GH/IGF-1 output while maintaining selectivity and minimizing side effects.
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Fat Metabolism and LipolysisInvestigations indicate enhanced lipolytic activity and reductions in fat mass in preclinical obesity and metabolic models, often attributed to elevated GH levels and improved insulin sensitivity in certain contexts.
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Tissue Repair and RecoveryStudies suggest benefits in accelerating wound healing, tendon/ligament repair, cartilage regeneration, and bone metabolism through GH/IGF-1-mediated pathways. Research explores its role in models of aging, traumatic injury, and surgical recovery.
Storage & Handling
Storage & Handling
Lyophilised vials are stable at −20°C for up to 2 years unopened. Once reconstituted, refrigerate at 2–8°C and use within 28 days. Avoid repeated freeze-thaw cycles.
Beyond Use Date
Pre-filled formats (cartridge, pen, nasal) carry a beyond-use date of typically 4–8 weeks from receipt. ≥98% purity by HPLC. For in vitro and preclinical research use only — not for human or veterinary use.