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Omni Peptides

DSIP

Regular price Dhs. 250.00 AED
Regular price Sale price Dhs. 250.00 AED
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Improves sleep architecture, recovery, stress resilience

DSIP (Delta Sleep-Inducing Peptide, also known as Emideltide or Deltaran) is a synthetic nonapeptide originally isolated from cerebral venous blood of rabbits during induced sleep states. This research compound has attracted considerable scientific interest for its potential roles in sleep regulation, stress adaptation, and neuroendocrine modulation. Preliminary and advanced preclinical studies suggest that DSIP may promote delta-wave (slow-wave) sleep, reduce motor activity, exert stress-protective effects, modulate pain perception, and influence circadian rhythms without typical sedative mechanisms. Researchers utilize this peptide in laboratory and animal models to investigate mechanisms of sleep architecture, stress resilience, opioid/alcohol withdrawal, and neuroprotection. As a research-grade compound, DSIP is intended exclusively for in vitro and animal studies. Scientists value its amphiphilic nature, presence in multiple tissues (including brain, pituitary, and peripheral organs), and capacity to provide insights into endogenous hypnogenic and adaptive peptide signaling.

Molecular Formula
C₃₅H₄₈N₁₀O₁₅
Molecular Weight
848.8 g/mol
Sequence
Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
  • Sleep Regulation and Architecture
    Preclinical investigations demonstrate that DSIP induces spindle and delta EEG activity, enhances slow-wave sleep, and normalizes sleep patterns in various animal models (e.g., rabbits, rats, mice). Studies explore its correlation with circadian rhythms, plasma levels during sleep transitions, and potential to improve sleep efficiency without suppressing REM sleep.
  • Stress Protection and Adaptation
    DSIP exhibits robust stress-limiting effects, reducing manifestations of acute and chronic stress, modulating HPA axis activity (e.g., decreasing corticotropin), and enhancing tolerance to psychic and physiological stressors in animal models. Research highlights its role in counteracting withdrawal symptoms from opioids and alcohol.
  • Pain Modulation and Analgesia
    Investigations indicate potent antinociceptive properties, particularly with central administration, suggesting interactions with opiate systems and potential benefits in models of chronic pain, neuropathic conditions, and fibromyalgia.
  • Neuroprotection and Antioxidant Effects
    DSIP protects against oxidative stress, enhances mitochondrial function (e.g., oxidative phosphorylation), and exhibits neuroprotective actions in models of neurodegeneration, epilepsy (anticonvulsant effects), and age-related decline. Studies also suggest antimutagenic and potential anticarcinogenic activity (e.g., reduced spontaneous tumor incidence in mice).
  • Broader Endocrine and Physiological Effects
    Research shows DSIP influences thermoregulation, blood pressure, myocardial function, hormonal release (e.g., stimulating LH and GH while inhibiting somatostatin), and immune modulation, with implications for aging, metabolic health, and recovery from various insults.
Storage & Handling

Lyophilised vials are stable at −20°C for up to 2 years unopened. Once reconstituted, refrigerate at 2–8°C and use within 28 days. Avoid repeated freeze-thaw cycles.

Beyond Use Date

Pre-filled formats (cartridge, pen, nasal) carry a beyond-use date of typically 4–8 weeks from receipt. ≥98% purity by HPLC. For in vitro and preclinical research use only — not for human or veterinary use.