Omni Peptides
FOXO4-DRI
Couldn't load pickup availability
FOXO4-DRI (also known as FOXO4-D-Retro-Inverso, Proxofim, or FOXO4-DRI peptide) is a synthetic cell-permeable retro-inverso peptide composed entirely of D-amino acids. It is designed as a competitive antagonist that mimics the p53-binding domain of the FOXO4 (Forkhead box O4) transcription factor, thereby selectively disrupting the FOXO4-p53 interaction. This research compound has attracted substantial scientific interest as a prototype senolytic agent that preferentially induces apoptosis in senescent cells while largely sparing healthy proliferating cells. Preliminary and advanced preclinical studies demonstrate that FOXO4-DRI promotes nuclear exclusion of p53 in senescent cells, redirects it toward mitochondrial pathways, triggers cytochrome c release and caspase activation, and ultimately clears senescent populations. Researchers utilize FOXO4-DRI in laboratory and animal models to investigate mechanisms of cellular senescence, tissue homeostasis restoration, age-related pathologies, chemotherapy-induced toxicity, and regenerative interventions. As a research-grade compound, FOXO4-DRI is intended exclusively for in vitro and animal studies. Scientists value its high selectivity, enhanced proteolytic stability due to the D-amino acid and retro-inverso design, and its role in advancing understanding of FOXO4-p53 axis-mediated senescence survival.
Research Applications
Storage & Handling
Storage & Handling
Lyophilised vials are stable at −20°C for up to 2 years unopened. Once reconstituted, refrigerate at 2–8°C and use within 28 days. Avoid repeated freeze-thaw cycles.
Beyond Use Date
Pre-filled formats (cartridge, pen, nasal) carry a beyond-use date of typically 4–8 weeks from receipt. ≥98% purity by HPLC. For in vitro and preclinical research use only — not for human or veterinary use.
— About this compound
FOXO4-DRI is a synthetic retro-inverso peptide.
FOXO4-DRI (also known as FOXO4-D-Retro-Inverso, Proxofim, or FOXO4-DRI peptide) is a synthetic cell-permeable retro-inverso peptide composed entirely of D-amino acids. It is designed as a competitive antagonist that mimics the p53-binding domain of the FOXO4 (Forkhead box O4) transcription factor, thereby selectively disrupting the FOXO4-p53 interaction. This research compound has attracted substantial scientific interest as a prototype senolytic agent that preferentially induces apoptosis in senescent cells while largely sparing healthy proliferating cells. Preliminary and advanced preclinical studies demonstrate that FOXO4-DRI promotes nuclear exclusion of p53 in senescent cells, redirects it toward mitochondrial pathways, triggers cytochrome c release and caspase activation, and ultimately clears senescent populations. Researchers utilize FOXO4-DRI in laboratory and animal models to investigate mechanisms of cellular senescence, tissue homeostasis restoration, age-related pathologies, chemotherapy-induced toxicity, and regenerative interventions. As a research-grade compound, FOXO4-DRI is intended exclusively for in vitro and animal studies. Scientists value its high selectivity, enhanced proteolytic stability due to the D-amino acid and retro-inverso design, and its role in advancing understanding of FOXO4-p53 axis-mediated senescence survival.
Research Applications
Where researchers apply it.
— Verified & Documented
Every vial is backed by a Certificate of Analysis.
Each lot is independently characterised by HPLC and mass spectrometry, with identity, mass and purity documented per batch and available on request.
Additional quality-control testing, including sterility, endotoxin and heavy metals, is conducted periodically across our product range.
Storage & Handling
Storage & Handling
Lyophilised vials are stable at −20°C for up to 2 years unopened. Once reconstituted, refrigerate at 2–8°C and use within 28 days. Avoid repeated freeze-thaw cycles.
Beyond Use Date
Pre-filled formats (cartridge, pen, nasal) carry a beyond-use date of typically 4–8 weeks from receipt. ≥98% purity by HPLC. For in vitro and preclinical research use only — not for human or veterinary use.