Omni Peptides
Humanin
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Humanin is a synthetic mitochondrial-derived peptide (MDP) consisting of 24 amino acids, encoded by a short open reading frame within the 16S ribosomal RNA gene (MT-RNR2) of the mitochondrial genome. This research compound has attracted substantial scientific interest as one of the most potent and well-characterized cytoprotective and neuroprotective peptides identified to date. Preliminary and advanced preclinical studies demonstrate that humanin exerts broad protective effects against cellular stress, apoptosis, oxidative damage, and inflammation through multiple mechanisms, including interaction with extracellular receptors (e.g., FPRL1/formyl peptide receptor-like 1), intracellular binding partners (e.g., Bax, Bid, IGFBP-3), and modulation of STAT3, ERK, and AKT signaling pathways. Researchers utilize humanin (and its more potent analogs such as HNG or HN-F6A) in laboratory and animal models to investigate mechanisms of mitochondrial-mediated cytoprotection, neurodegeneration, metabolic disorders, cardiovascular disease, and aging-related pathologies. As a research-grade compound, humanin is intended exclusively for in vitro and animal studies. Scientists value its remarkable potency at nanomolar to picomolar concentrations, its ability to cross the blood-brain barrier, and its potential as a prototype for developing mitochondrially-targeted therapeutics.
Research Applications
Storage & Handling
Storage & Handling
Lyophilised vials are stable at −20°C for up to 2 years unopened. Once reconstituted, refrigerate at 2–8°C and use within 28 days. Avoid repeated freeze-thaw cycles.
Beyond Use Date
Pre-filled formats (cartridge, pen, nasal) carry a beyond-use date of typically 4–8 weeks from receipt. ≥98% purity by HPLC. For in vitro and preclinical research use only — not for human or veterinary use.
— About this compound
Humanin is a synthetic mitochondria-derived cytoprotective peptide.
Humanin is a synthetic mitochondrial-derived peptide (MDP) consisting of 24 amino acids, encoded by a short open reading frame within the 16S ribosomal RNA gene (MT-RNR2) of the mitochondrial genome. This research compound has attracted substantial scientific interest as one of the most potent and well-characterized cytoprotective and neuroprotective peptides identified to date. Preliminary and advanced preclinical studies demonstrate that humanin exerts broad protective effects against cellular stress, apoptosis, oxidative damage, and inflammation through multiple mechanisms, including interaction with extracellular receptors (e.g., FPRL1/formyl peptide receptor-like 1), intracellular binding partners (e.g., Bax, Bid, IGFBP-3), and modulation of STAT3, ERK, and AKT signaling pathways. Researchers utilize humanin (and its more potent analogs such as HNG or HN-F6A) in laboratory and animal models to investigate mechanisms of mitochondrial-mediated cytoprotection, neurodegeneration, metabolic disorders, cardiovascular disease, and aging-related pathologies. As a research-grade compound, humanin is intended exclusively for in vitro and animal studies. Scientists value its remarkable potency at nanomolar to picomolar concentrations, its ability to cross the blood-brain barrier, and its potential as a prototype for developing mitochondrially-targeted therapeutics.
Research Applications
Where researchers apply it.
— Verified & Documented
Every vial is backed by a Certificate of Analysis.
Each lot is independently characterised by HPLC and mass spectrometry, with identity, mass and purity documented per batch and available on request.
Additional quality-control testing, including sterility, endotoxin and heavy metals, is conducted periodically across our product range.
Storage & Handling
Storage & Handling
Lyophilised vials are stable at −20°C for up to 2 years unopened. Once reconstituted, refrigerate at 2–8°C and use within 28 days. Avoid repeated freeze-thaw cycles.
Beyond Use Date
Pre-filled formats (cartridge, pen, nasal) carry a beyond-use date of typically 4–8 weeks from receipt. ≥98% purity by HPLC. For in vitro and preclinical research use only — not for human or veterinary use.