Omni Peptides
KissPeptin-10
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Can raise LH/FSH/testosterone transiently; reproductive axis modulation
Kisspeptin-10 (also known as Kp-10 or Metastin (45-54)) is a synthetic decapeptide corresponding to the C-terminal bioactive fragment (residues 45-54) of the KISS1 gene product, a key upstream regulator of the hypothalamic-pituitary-gonadal (HPG) axis. This research compound has attracted extensive scientific interest for its potent stimulation of gonadotropin-releasing hormone (GnRH) secretion and its role in reproductive endocrinology. Preliminary and advanced preclinical studies indicate that Kisspeptin-10 may robustly increase luteinizing hormone (LH) and follicle-stimulating hormone (FSH) release, support gonadotropin pulsatility, and influence reproductive behaviors and fertility. Researchers utilize this peptide in laboratory and animal models to investigate mechanisms of puberty onset, HPG axis regulation, hypogonadism, and neuroendocrine signaling. As a research-grade compound, Kisspeptin-10 is intended exclusively for in vitro and animal studies. Scientists value its high potency as a GPR54 (KISS1R) agonist, short half-life, and utility in elucidating kisspeptin-mediated control of reproduction and related pathologies.
Research Applications
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Hypothalamic-Pituitary-Gonadal Axis StimulationPreclinical studies demonstrate that Kisspeptin-10 potently elicits dose-dependent increases in LH and FSH secretion via direct activation of GnRH neurons. It enhances LH pulse frequency and amplitude in various models, including rodents and non-human primates, highlighting its central role in gonadotropin regulation.
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Fertility and Reproductive Hormone RestorationInvestigations show Kisspeptin-10 restores gonadal function in models of hypogonadotropic hypogonadism, hyperprolactinemia, and hypothyroidism, improving testosterone levels, testicular morphology, and sperm quality. It has been explored for reversing infertility states and supporting ovulation induction.
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Puberty Onset and Sexual MaturationResearch indicates Kisspeptin-10 advances pubertal development in prepubertal models and modulates sexual dimorphism in hormone responses, with implications for studying delayed or precocious puberty and sex-specific reproductive timing.
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Reproductive Behavior and Sexual FunctionStudies reveal effects on sexual motivation, partner preference, and arousal pathways, including modulation of brain activity in sexual-processing networks and potential benefits in models of hypoactive sexual desire disorder (HSDD).
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Broader Metabolic and Endocrine EffectsEmerging preclinical data suggest influences on energy balance, metabolic regulation in obesity-diabetes models, and interactions with other neuroendocrine systems, including potential roles in insulin sensitivity and gonadal steroidogenesis.
Storage & Handling
Storage & Handling
Lyophilised vials are stable at −20°C for up to 2 years unopened. Once reconstituted, refrigerate at 2–8°C and use within 28 days. Avoid repeated freeze-thaw cycles.
Beyond Use Date
Pre-filled formats (cartridge, pen, nasal) carry a beyond-use date of typically 4–8 weeks from receipt. ≥98% purity by HPLC. For in vitro and preclinical research use only — not for human or veterinary use.