Omni Peptides
KPV
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Reduces inflammation, aids wound healing and GI repair
KPV is a synthetic tripeptide corresponding to the C-terminal sequence (residues 11-13) of alpha-melanocyte-stimulating hormone (α-MSH), a naturally occurring peptide with immunomodulatory properties. This research compound has garnered considerable scientific interest for its potent anti-inflammatory and tissue-protective effects in preclinical models. Preliminary studies suggest that KPV may attenuate inflammatory signaling pathways, reduce cytokine production, and support epithelial barrier function. Researchers utilize this peptide in laboratory settings to investigate mechanisms of inflammation resolution, particularly in models of gastrointestinal, dermal, and mucosal injury. As a research-grade compound, KPV is intended exclusively for in vitro and animal studies. Scientists value its potential to elucidate non-melanocortin receptor-mediated anti-inflammatory pathways.
Research Applications
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Gastrointestinal Health and Mucosal RepairPreclinical investigations demonstrate that KPV effectively reduces inflammation in models of inflammatory bowel disease (IBD), colitis, and oral mucositis. It promotes mucosal healing, attenuates pro-inflammatory cytokine expression, and supports gut barrier integrity via PepT1-mediated uptake.
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Dermal and Wound HealingKPV accelerates wound closure and re-epithelialization in cutaneous and corneal injury models. Studies highlight its role in reducing scar formation, enhancing collagen organization, and promoting tissue regeneration in chronic ulcers and inflammatory skin conditions.
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Anti-Inflammatory and Immunomodulatory EffectsKPV potently inhibits NF-κB and MAPK signaling pathways, decreasing production of pro-inflammatory cytokines such as TNF-α, IL-1β, IL-6, and IL-8. It shifts cellular responses toward resolution of inflammation without melanogenic activity.
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Antimicrobial PropertiesResearch indicates KPV exhibits direct antimicrobial effects against pathogens like Staphylococcus aureus and Candida albicans, complementing its anti-inflammatory actions in infected wound models.
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Broader Tissue ProtectionPreliminary data suggest potential benefits in reducing fibrosis, oxidative stress, and immune-mediated damage in various organ systems, including ocular and bronchial tissues.
Storage & Handling
Storage & Handling
Lyophilised vials are stable at −20°C for up to 2 years unopened. Once reconstituted, refrigerate at 2–8°C and use within 28 days. Avoid repeated freeze-thaw cycles.
Beyond Use Date
Pre-filled formats (cartridge, pen, nasal) carry a beyond-use date of typically 4–8 weeks from receipt. ≥98% purity by HPLC. For in vitro and preclinical research use only — not for human or veterinary use.