Omni Peptides
MOTS-c
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Clean GH boost, recovery, fat metabolism
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA type-c) is a synthetic version of the naturally occurring 16-amino-acid mitochondrial-derived peptide (MDP) encoded by a short open reading frame within the mitochondrial 12S rRNA gene (MT-RNR1). This research compound has attracted significant scientific interest for its role as a metabolic regulator and exercise mimetic. Preliminary and advanced preclinical studies indicate that MOTS-c may activate AMP-activated protein kinase (AMPK), enhance glucose uptake in skeletal muscle, promote metabolic flexibility, reduce insulin resistance, and support mitochondrial biogenesis. Researchers utilize this peptide in laboratory and animal models to explore mechanisms of energy homeostasis, particularly in models of obesity, type 2 diabetes, aging, and exercise physiology. As a research-grade compound, MOTS-c is intended exclusively for in vitro and animal studies. Scientists value its unique mitochondrial origin, systemic hormonal-like actions, and potential to elucidate mitochondrial-nuclear communication in metabolic health.
Research Applications
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Metabolic Homeostasis and Insulin SensitivityPreclinical investigations show that MOTS-c improves insulin sensitivity, enhances glucose uptake in skeletal muscle via the folate-AICAR-AMPK pathway, and counters high-fat diet-induced insulin resistance and obesity in various models.
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Exercise Mimetic EffectsMOTS-c is upregulated in response to exercise and mimics many of its benefits, including increased energy expenditure, improved physical performance, and metabolic adaptations in skeletal muscle, with enhanced endurance observed in aged and obese animal models.
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Obesity and Weight ManagementStudies demonstrate that MOTS-c reduces body weight gain, promotes fat oxidation, and prevents diet-induced obesity through modulation of lipid metabolism and thermogenesis in adipose tissue.
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Aging and Longevity SupportResearch highlights its role in counteracting age-related metabolic decline, improving muscle function, and potentially extending healthspan by enhancing mitochondrial stress responses and reducing oxidative damage.
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Broader Protective EffectsInvestigations suggest benefits in bone metabolism regulation (promoting osteoblast activity and inhibiting osteoclastogenesis), liver health (reducing steatosis in NAFLD models), anti-inflammatory actions, and protection against metabolic stress in various organ systems.
Storage & Handling
Storage & Handling
Lyophilised vials are stable at −20°C for up to 2 years unopened. Once reconstituted, refrigerate at 2–8°C and use within 28 days. Avoid repeated freeze-thaw cycles.
Beyond Use Date
Pre-filled formats (cartridge, pen, nasal) carry a beyond-use date of typically 4–8 weeks from receipt. ≥98% purity by HPLC. For in vitro and preclinical research use only — not for human or veterinary use.