Omni Peptides
N-Acetyl Selank Amidate
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N-Acetyl Selank Amidate (also known as Ac-Selank-NH₂ or N-Acetyl TP-7 Amidate) is a synthetic heptapeptide derived from Selank with two key modifications: N-terminal acetylation and C-terminal amidation. These changes enhance enzymatic stability, improve blood-brain barrier penetration, and potentially prolong biological activity compared to standard Selank. It retains the core sequence of the tuftsin analog (Thr-Lys-Pro-Arg-Pro-Gly-Pro) and is studied for its anxiolytic, nootropic, neuroprotective, and immunomodulatory properties. Preclinical research suggests it modulates GABAergic, serotonergic, and BDNF pathways while offering greater resistance to degradation. Researchers utilize N-Acetyl Selank Amidate in laboratory and animal models to investigate stress resilience, cognitive enhancement, neuroinflammation, and optimized peptide delivery. As a research-grade compound, it is intended exclusively for in vitro and animal studies. Scientists value its improved pharmacokinetic profile and potential for enhanced CNS effects.
Research Applications
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Anxiolytic and Anti-Stress EffectsPreclinical models show strong anxiety-reducing properties in behavioral tests (elevated plus-maze, open-field) with modulation of serotonin and enkephalin systems, without sedation or memory impairment.
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Cognitive Enhancement and NeuroplasticityStudies explore improvements in memory, learning, attention, and adaptive behavior under stress or aging conditions, with potential upregulation of BDNF and hippocampal function.
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Neuroprotection and Anti-Inflammatory ActionResearch indicates reduced neuroinflammation, oxidative stress, and neuronal damage in ischemia, stress, and neurodegeneration models through cytokine modulation and glial regulation.
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ImmunomodulationIt may normalize stress-induced immune imbalances, supporting T-cell function and cytokine balance.
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Peptide OptimizationThe dual modification (N-acetylation + C-amidation) is frequently studied for superior stability, longer half-life, and better receptor interactions compared to unmodified or singly modified Selank variants.
Storage & Handling
Storage & Handling
Lyophilised vials are stable at −20°C for up to 2 years unopened. Once reconstituted, refrigerate at 2–8°C and use within 28 days. Avoid repeated freeze-thaw cycles.
Beyond Use Date
Pre-filled formats (cartridge, pen, nasal) carry a beyond-use date of typically 4–8 weeks from receipt. ≥98% purity by HPLC. For in vitro and preclinical research use only — not for human or veterinary use.