Omni Peptides
NAD+
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Mitochondrial function, cognitive support, anti-aging
NAD+ (Nicotinamide Adenine Dinucleotide) is a synthetic or recombinantly produced form of the naturally occurring essential pyridine nucleotide coenzyme found in all living cells. This research compound serves as a critical cofactor in redox reactions, a substrate for enzymes involved in DNA repair, gene expression, and cellular signaling. It has garnered extensive scientific interest for its central role in mitochondrial function, energy metabolism, and age-related decline. Preliminary and advanced preclinical studies indicate that direct NAD+ supplementation or restoration may enhance cellular bioenergetics, support sirtuin and PARP activity, reduce oxidative stress, and promote mitochondrial biogenesis. Researchers utilize NAD+ in laboratory settings to investigate mechanisms of cellular aging, metabolic disorders, neurodegeneration, and tissue repair, often in models where NAD+ levels are depleted. As a research-grade compound, NAD+ is intended exclusively for in vitro and animal studies. Scientists value its direct impact on NAD+-dependent pathways, though challenges with stability and bioavailability often lead to complementary use with precursors like NMN or NR in experimental designs.
Research Applications
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Mitochondrial Function and BioenergeticsPreclinical investigations demonstrate that NAD+ restoration improves oxidative phosphorylation, ATP production, and mitochondrial dynamics in models of aging, ischemia-reperfusion injury, and metabolic dysfunction, often reversing age-associated mitochondrial decline.
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Aging and Longevity PathwaysExtensive studies in animal models show NAD+ supplementation counters age-related NAD+ depletion, activates sirtuins (e.g., SIRT1), enhances DNA repair via PARPs, reduces inflammation, and promotes healthspan extension in contexts of sarcopenia, neurodegeneration, and systemic aging.
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Neuroprotection and CNS DisordersResearch highlights NAD+'s protective effects in models of Alzheimer's disease, Parkinson's disease, traumatic brain injury, and stroke by mitigating oxidative stress, apoptosis, and neuroinflammation while supporting neuronal energy metabolism and synaptic function.
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Metabolic Health and Insulin SensitivityNAD+ modulates glucose homeostasis, improves insulin signaling, reduces lipid accumulation, and protects against diet-induced obesity and type 2 diabetes in various preclinical models through enhanced metabolic flexibility and reduced inflammation.
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Cardiovascular and Tissue ProtectionInvestigations reveal benefits in ischemia-reperfusion models, where NAD+ reduces infarct size, improves cardiac function, and supports vascular integrity, alongside broader cytoprotective effects in liver, muscle, and other organs under stress.
Storage & Handling
Storage & Handling
Lyophilised vials are stable at −20°C for up to 2 years unopened. Once reconstituted, refrigerate at 2–8°C and use within 28 days. Avoid repeated freeze-thaw cycles.
Beyond Use Date
Pre-filled formats (cartridge, pen, nasal) carry a beyond-use date of typically 4–8 weeks from receipt. ≥98% purity by HPLC. For in vitro and preclinical research use only — not for human or veterinary use.