• SNAP-8 octapeptide lyophilised research peptide vial – Dubai Peptides UAE
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Omni Peptides

SNAP-8

Dhs. 300.00 AED
Dhs. 300.00 AED
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Size
Lyophilised & sealed vials
Independent COA · ≥99% purity
Cold-chain dispatch · same day Dubai
Discreet · unbranded outer packaging

Wrinkle reduction, smoother skin (topical)

SNAP-8 (also known as Acetyl Octapeptide-3) is a synthetic octapeptide analog of SNAP-25 (Synaptosomal-Associated Protein 25), specifically designed as an extended and optimized version of the hexapeptide Argireline (Acetyl Hexapeptide-3). This research compound has garnered considerable scientific interest for its potential to modulate neurotransmitter release at the neuromuscular junction when applied topically in ex vivo and in vitro skin models. Preliminary and advanced studies suggest that SNAP-8 may competitively inhibit SNARE complex formation, reduce acetylcholine exocytosis from peripheral nerve terminals, and thereby attenuate repetitive facial muscle contractions that contribute to dynamic expression lines. Researchers utilize this peptide in laboratory settings—primarily in human skin explants, 3D reconstructed epidermis models, and innervated skin equivalents—to investigate mechanisms of topical neuromuscular relaxation, wrinkle depth reduction, and non-invasive modulation of cutaneous expression dynamics. As a research-grade compound, SNAP-8 is intended exclusively for in vitro, ex vivo, and topical formulation studies. Scientists value its improved skin penetration, enhanced potency, and greater duration of effect compared to shorter analogs, as well as its utility in advancing understanding of SNARE-mediated neurotransmission in cutaneous physiology and topical cosmeceutical research.

Molecular Formula
C₄₁H₇₀N₁₆O₁₆
Molecular Weight
1075.2 g/mol
Sequence
Ac-Glu-Glu-Met-Gln-Arg-Arg-Arg-Glu-NH₂ (N-terminal acetylation, C-terminal amidation)

Research Applications

01 Topical Neuromuscular Transmission Modulation
Ex vivo and in vitro studies demonstrate that SNAP-8, when applied topically, inhibits SNAP-25-dependent SNARE complex assembly in peripheral nerve endings within the dermis, leading to dose-dependent reduction in acetylcholine release and subsequent attenuation of muscle fiber contraction in innervated skin models.
02 Dynamic Wrinkle Reduction and Expression Line Research
Extensive organotypic skin explant and 3D skin model investigations show SNAP-8 significantly decreases the depth, length, and visibility of dynamic wrinkles (crow’s feet, forehead lines, glabellar furrows) by limiting repetitive muscle contractions. Comparative studies frequently report superior efficacy, penetration, and persistence compared to Acetyl Hexapeptide-3.
03 Skin Smoothening and Anti-Wrinkle Mechanisms
Research highlights SNAP-8’s ability to reduce mechanical stress transmitted from facial mimetic muscles to the dermis, potentially preserving collagen and elastin fiber organization over time. Studies explore secondary effects on fibroblast mechanotransduction and extracellular matrix remodeling.
04 Topical Formulation and Delivery Optimization
SNAP-8 is widely investigated in various topical vehicles (creams, serums, gels, liposomes, nanoemulsions, microneedle patches) to assess stability, stratum corneum penetration, sustained release, and bioavailability. Research examines synergies with penetration enhancers, hyaluronic acid, other peptides, and delivery systems to maximize transdermal efficacy.
05 Selectivity for Facial Mimetic Muscles
Preclinical ex vivo models suggest SNAP-8 exhibits preferential effects on superficial facial mimetic muscles compared to deeper skeletal muscle, offering insights into targeted topical modulation of expression-related muscle activity without systemic neuromuscular impact.

Storage & Handling

Storage & Handling

Lyophilised vials are stable at −20°C for up to 2 years unopened. Once reconstituted, refrigerate at 2–8°C and use within 28 days. Avoid repeated freeze-thaw cycles.

Beyond Use Date

Pre-filled formats (cartridge, pen, nasal) carry a beyond-use date of typically 4–8 weeks from receipt. ≥98% purity by HPLC. For in vitro and preclinical research use only — not for human or veterinary use.

Molecular Formula
C₄₁H₇₀N₁₆O₁₆
Molecular Weight
1075.2 g/mol
Sequence
Ac-Glu-Glu-Met-Gln-Arg-Arg-Arg-Glu-NH₂ (N-terminal acetylation, C-terminal amidation)

— About this compound

SNAP-8 is a synthetic octapeptide signal peptide.

SNAP-8 (also known as Acetyl Octapeptide-3) is a synthetic octapeptide analog of SNAP-25 (Synaptosomal-Associated Protein 25), specifically designed as an extended and optimized version of the hexapeptide Argireline (Acetyl Hexapeptide-3). This research compound has garnered considerable scientific interest for its potential to modulate neurotransmitter release at the neuromuscular junction when applied topically in ex vivo and in vitro skin models. Preliminary and advanced studies suggest that SNAP-8 may competitively inhibit SNARE complex formation, reduce acetylcholine exocytosis from peripheral nerve terminals, and thereby attenuate repetitive facial muscle contractions that contribute to dynamic expression lines. Researchers utilize this peptide in laboratory settings—primarily in human skin explants, 3D reconstructed epidermis models, and innervated skin equivalents—to investigate mechanisms of topical neuromuscular relaxation, wrinkle depth reduction, and non-invasive modulation of cutaneous expression dynamics. As a research-grade compound, SNAP-8 is intended exclusively for in vitro, ex vivo, and topical formulation studies. Scientists value its improved skin penetration, enhanced potency, and greater duration of effect compared to shorter analogs, as well as its utility in advancing understanding of SNARE-mediated neurotransmission in cutaneous physiology and topical cosmeceutical research.

VIAL ANATOMY
LYOPHILISED VIAL
Flip-off cap
Tamper-evident seal
Rubber stopper
Bacteriostatic-water compatible
Batch-labelled body
Lot & expiry printed
USP Type I glass
Borosilicate, sealed
SNAP-8 vial
SNAP-8
10mg
DUBAI PEPTIDES
RESEARCH USE ONLY
BLACK RESEARCH SERIES

Research Applications

Where researchers apply it.

01 Topical Neuromuscular Transmission Modulation
Ex vivo and in vitro studies demonstrate that SNAP-8, when applied topically, inhibits SNAP-25-dependent SNARE complex assembly in peripheral nerve endings within the dermis, leading to dose-dependent reduction in acetylcholine release and subsequent attenuation of muscle fiber contraction in innervated skin models.
02 Dynamic Wrinkle Reduction and Expression Line Research
Extensive organotypic skin explant and 3D skin model investigations show SNAP-8 significantly decreases the depth, length, and visibility of dynamic wrinkles (crow’s feet, forehead lines, glabellar furrows) by limiting repetitive muscle contractions. Comparative studies frequently report superior efficacy, penetration, and persistence compared to Acetyl Hexapeptide-3.
03 Skin Smoothening and Anti-Wrinkle Mechanisms
Research highlights SNAP-8’s ability to reduce mechanical stress transmitted from facial mimetic muscles to the dermis, potentially preserving collagen and elastin fiber organization over time. Studies explore secondary effects on fibroblast mechanotransduction and extracellular matrix remodeling.
04 Topical Formulation and Delivery Optimization
SNAP-8 is widely investigated in various topical vehicles (creams, serums, gels, liposomes, nanoemulsions, microneedle patches) to assess stability, stratum corneum penetration, sustained release, and bioavailability. Research examines synergies with penetration enhancers, hyaluronic acid, other peptides, and delivery systems to maximize transdermal efficacy.
05 Selectivity for Facial Mimetic Muscles
Preclinical ex vivo models suggest SNAP-8 exhibits preferential effects on superficial facial mimetic muscles compared to deeper skeletal muscle, offering insights into targeted topical modulation of expression-related muscle activity without systemic neuromuscular impact.

— Verified & Documented

Every vial is backed by a Certificate of Analysis.

Each lot is independently characterised by HPLC and mass spectrometry, with identity, mass and purity documented per batch and available on request.

Additional quality-control testing, including sterility, endotoxin and heavy metals, is conducted periodically across our product range.

>99%
HPLC Purity
MS
Identity Confirmed
Certificate of Analysis
SNAP-8 · QC RELEASE
PASS
IdentityConfirmed
Mass—
Purity>99%
AppearanceWhite Lyophilised
LabJanoshik Analytical (Independant)
Date

Storage & Handling

Storage & Handling

Lyophilised vials are stable at −20°C for up to 2 years unopened. Once reconstituted, refrigerate at 2–8°C and use within 28 days. Avoid repeated freeze-thaw cycles.

Beyond Use Date

Pre-filled formats (cartridge, pen, nasal) carry a beyond-use date of typically 4–8 weeks from receipt. ≥98% purity by HPLC. For in vitro and preclinical research use only — not for human or veterinary use.