Omni Peptides

SNAP-8

Dhs. 300.00 AED

Sale Sold out

VIAL

Freeze-dried powder in a sealed glass vial. Reconstitute with bacteriostatic water and administer via syringe. The most versatile and cost-effective research format.

RECONSTITUTION & SYRINGE REQUIRED

CARTRIDGE

Pre-filled and ready to administer. Slides into a reusable pen injector — no measuring or mixing required. Clean, discreet, and consistent across research protocols.

REQUIRES COMPATIBLE PEN INJECTOR

NASAL

Delivered via mucosal absorption — no needles required. A popular choice for research protocols where needle-free administration is preferred.

NEEDLE-FREE — SPRAY & GO

PEN

An all-in-one auto-injector with the cartridge pre-loaded. Dial, click, and administer. Optimal for high-frequency research protocols requiring precise, repeatable dosing.

DIAL, CLICK & INJECT — NO PREP

Vials are freeze-dried (lyophilised) powder — kept refrigerated unopened, they remain stable for up to 2 years.

Cartridges, nasal sprays, and pens arrive pre-filled as liquid, must be kept refrigerated at all times, and carry a Beyond Use Date — typically 4–8 weeks from receipt. Please refer to the BUD on the label.

Size 10mg

Wrinkle reduction, smoother skin (topical)

SNAP-8 (also known as Acetyl Octapeptide-3) is a synthetic octapeptide analog of SNAP-25 (Synaptosomal-Associated Protein 25), specifically designed as an extended and optimized version of the hexapeptide Argireline (Acetyl Hexapeptide-3). This research compound has garnered considerable scientific interest for its potential to modulate neurotransmitter release at the neuromuscular junction when applied topically in ex vivo and in vitro skin models. Preliminary and advanced studies suggest that SNAP-8 may competitively inhibit SNARE complex formation, reduce acetylcholine exocytosis from peripheral nerve terminals, and thereby attenuate repetitive facial muscle contractions that contribute to dynamic expression lines. Researchers utilize this peptide in laboratory settings—primarily in human skin explants, 3D reconstructed epidermis models, and innervated skin equivalents—to investigate mechanisms of topical neuromuscular relaxation, wrinkle depth reduction, and non-invasive modulation of cutaneous expression dynamics. As a research-grade compound, SNAP-8 is intended exclusively for in vitro, ex vivo, and topical formulation studies. Scientists value its improved skin penetration, enhanced potency, and greater duration of effect compared to shorter analogs, as well as its utility in advancing understanding of SNARE-mediated neurotransmission in cutaneous physiology and topical cosmeceutical research.

Molecular Formula

C₄₁H₇₀N₁₆O₁₆

Molecular Weight

1075.2 g/mol

Sequence

Ac-Glu-Glu-Met-Gln-Arg-Arg-Arg-Glu-NH₂ (N-terminal acetylation, C-terminal amidation)

Research Applications

Topical Neuromuscular Transmission Modulation
Ex vivo and in vitro studies demonstrate that SNAP-8, when applied topically, inhibits SNAP-25-dependent SNARE complex assembly in peripheral nerve endings within the dermis, leading to dose-dependent reduction in acetylcholine release and subsequent attenuation of muscle fiber contraction in innervated skin models.
Dynamic Wrinkle Reduction and Expression Line Research
Extensive organotypic skin explant and 3D skin model investigations show SNAP-8 significantly decreases the depth, length, and visibility of dynamic wrinkles (crow’s feet, forehead lines, glabellar furrows) by limiting repetitive muscle contractions. Comparative studies frequently report superior efficacy, penetration, and persistence compared to Acetyl Hexapeptide-3.
Skin Smoothening and Anti-Wrinkle Mechanisms
Research highlights SNAP-8’s ability to reduce mechanical stress transmitted from facial mimetic muscles to the dermis, potentially preserving collagen and elastin fiber organization over time. Studies explore secondary effects on fibroblast mechanotransduction and extracellular matrix remodeling.
Topical Formulation and Delivery Optimization
SNAP-8 is widely investigated in various topical vehicles (creams, serums, gels, liposomes, nanoemulsions, microneedle patches) to assess stability, stratum corneum penetration, sustained release, and bioavailability. Research examines synergies with penetration enhancers, hyaluronic acid, other peptides, and delivery systems to maximize transdermal efficacy.
Selectivity for Facial Mimetic Muscles
Preclinical ex vivo models suggest SNAP-8 exhibits preferential effects on superficial facial mimetic muscles compared to deeper skeletal muscle, offering insights into targeted topical modulation of expression-related muscle activity without systemic neuromuscular impact.

Storage & Handling

Lyophilised vials are stable at −20°C for up to 2 years unopened. Once reconstituted, refrigerate at 2–8°C and use within 28 days. Avoid repeated freeze-thaw cycles.

Beyond Use Date

Pre-filled formats (cartridge, pen, nasal) carry a beyond-use date of typically 4–8 weeks from receipt. ≥98% purity by HPLC. For in vitro and preclinical research use only — not for human or veterinary use.