Omni Peptides
SS-31
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Mitochondria-repair peptide; energy, endurance, neuroprotection, anti-aging at cellular level
SS-31 (also known as Elamipretide, Bendavia, or MTP-131) is a synthetic tetrapeptide designed as a mitochondria-targeted antioxidant from the Szeto-Schiller (SS) series. This research compound selectively accumulates in the inner mitochondrial membrane by binding to cardiolipin, a phospholipid critical for electron transport chain organization. It has garnered extensive scientific interest for its ability to scavenge reactive oxygen species (ROS), stabilize mitochondrial structure, enhance ATP production, and reduce oxidative damage without relying on mitochondrial membrane potential. Researchers employ SS-31 in laboratory and animal models to investigate mitochondrial dysfunction in aging, neurodegeneration, cardiovascular disorders, renal injury, and other conditions linked to bioenergetic failure. As a research-grade compound, SS-31 is intended exclusively for in vitro and animal studies. Scientists value its remarkable cell permeability, high mitochondrial selectivity, and potential to elucidate cardiolipin-mediated mitochondrial protection mechanisms. (Note: Elamipretide has received regulatory approval for specific clinical indications such as Barth syndrome in some jurisdictions, but research formulations remain designated for laboratory use.)
Research Applications
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Mitochondrial Protection and BioenergeticsPreclinical studies demonstrate that SS-31 binds cardiolipin to optimize electron transport chain supercomplex assembly, improve oxidative phosphorylation coupling, increase ATP synthesis, and reduce ROS production in dysfunctional mitochondria across various models.
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Aging and Age-Related DeclineInvestigations show SS-31 reverses age-related redox stress, restores mitochondrial function in skeletal muscle and other tissues, improves exercise tolerance, and mitigates sarcopenia-like phenotypes in aged animal models.
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Neuroprotection and CNS DisordersSS-31 exhibits potent effects in models of Alzheimer's disease, ischemic brain injury, traumatic brain injury, and neurodegeneration by reducing Aβ production, preserving mitochondrial dynamics, inhibiting apoptosis, and protecting neural tissues from oxidative insults.
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Cardiovascular and Renal ProtectionResearch highlights its role in ameliorating ischemia-reperfusion injury, improving cardiac mitochondrial morphology (e.g., in Barth syndrome models), reducing glomerular damage in aged kidneys, and accelerating ATP recovery in ischemic tissues.
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Broader Tissue and Organ ProtectionStudies indicate benefits in reducing oxidative stress and inflammation in models of wound healing, liver injury, ophthalmic conditions, and other pathologies involving mitochondrial impairment, while promoting cellular resilience and repair.
Storage & Handling
Storage & Handling
Lyophilised vials are stable at −20°C for up to 2 years unopened. Once reconstituted, refrigerate at 2–8°C and use within 28 days. Avoid repeated freeze-thaw cycles.
Beyond Use Date
Pre-filled formats (cartridge, pen, nasal) carry a beyond-use date of typically 4–8 weeks from receipt. ≥98% purity by HPLC. For in vitro and preclinical research use only — not for human or veterinary use.