Omni Peptides
Epithalon
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Potential anti-aging, sleep improvements, cellular maintenance
Epithalon (also known as Epitalon or Epithalone) is a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Gly, derived from the naturally occurring pineal gland peptide complex Epithalamin. This research compound has attracted substantial scientific interest for its potential roles in telomere biology, geroprotection, and circadian regulation. Preliminary and advanced preclinical studies suggest that Epithalon may activate telomerase, promote telomere elongation, modulate pineal gland function (including melatonin synthesis), exert antioxidant effects, and influence gene expression related to aging and cellular repair. Researchers utilize this peptide in laboratory and animal models to investigate mechanisms of cellular senescence, longevity pathways, neuroendocrine signaling, and age-related decline. As a research-grade compound, Epithalon is intended exclusively for in vitro and animal studies. Scientists value its high stability, low molecular weight, and capacity to provide insights into pineal-derived peptide signaling in aging and regenerative biology.
Research Applications
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Telomere Maintenance and Telomerase ActivationPreclinical investigations demonstrate that Epithalon significantly increases telomerase activity in various cell types, supporting telomere length preservation and potentially extending replicative lifespan in cultured cells. Studies explore its effects on overcoming the Hayflick limit and maintaining genomic stability.
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Anti-Aging and Geroprotective EffectsExtensive research in animal models indicates Epithalon may extend lifespan, improve healthspan markers, and counteract age-related physiological decline. It has been studied for its influence on pineal gland function, antioxidant defenses, and modulation of proto-oncogenes in aging contexts.
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Circadian Rhythm and Pineal Gland RegulationEpithalon modulates melatonin production and pineal peptide signaling, restoring disrupted circadian rhythms in aged or stressed models. Investigations highlight its role in neuroendocrine normalization and clock gene expression.
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Antioxidant and Cellular ProtectionStudies show Epithalon reduces oxidative stress, scavenges reactive oxygen species, and protects against damage in models of hyperglycemia, post-ovulatory oocyte aging, diabetic retinopathy, and other oxidative insult scenarios, often comparable to melatonin.
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Broader Regenerative and Protective EffectsResearch suggests potential benefits in immune modulation (e.g., thymic function), wound healing, neuroprotection, and antimutagenic activity, with implications for age-related pathologies across multiple organ systems.
Storage & Handling
Storage & Handling
Lyophilised vials are stable at −20°C for up to 2 years unopened. Once reconstituted, refrigerate at 2–8°C and use within 28 days. Avoid repeated freeze-thaw cycles.
Beyond Use Date
Pre-filled formats (cartridge, pen, nasal) carry a beyond-use date of typically 4–8 weeks from receipt. ≥98% purity by HPLC. For in vitro and preclinical research use only — not for human or veterinary use.